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Cyclopamine Tartarate Salt

Cyclopamine Tartarate Salt (Hydroxy Carboxylic Acid) is a white crystaline compound that has been filed for a provisional patent by LNP on 2/10/2008.

Chemical Structure of Cyclopamine Tartarate Salt
Cyclopamine Tartarate Salt

Solubility and Stability

2 mg of Cyclopamine Tartarate Salt is soluble by stirring in 1 ml of deionized water (at room temperature). The solubility will increase to about 5 mg Cyclopamine Tartarate per 1 ml of deionized water when 1.5 mg tartaric acid is added to the solution at room temperature (increasing the temperature will increase the solubility). In each case the solution must be well stirred. LC-MS Analyses indicate that the aqueous solution of Cyclopamine Tartarate is stable for at least one week at room temperature. Pharmasolve ( N-Methyl -2-Pyrrolidone ), cGMP grade will increase its solubility to 1.0 % by weight in deionized water. This solution is stable for at least one week.