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Pricing

Please Contact Customer Service to arrange for orders of more than 1 gram.
Cyclopamine - 10 mg $70.00
Cyclopamine - 25 mg $140.00
Cyclopamine - 50 mg $270.00
Cyclopamine - 100 mg $520.00
Cyclopamine - 500 mg $2,300.00
Cyclopamine - 1 gram $4,300.00
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Physical Characteristics

  • Purity: Greater than 99%
  • Molecular Weight: 411.63
  • Molecular Formula: C27H41NO2
  • CAS Number: 4449-51-8
  • RTECS Number: GY0750000
  • Synonyms: 11-Deoxyjervine

Handling Instructions

  • Gloves and mask should be worn when using this compound.
  • Care must be given to prevent contact through all routes of exposure.
  • Women of childbearing age should be extremely cautious in handling cyclopamine.
  • Store at or below: -20ยบ C
  • Disposal: A

Note: All products are intended for research use only, Customer assumes all responsibility for misuse or mishandling of products.

Cyclopamine

Cyclopamine is a steroidal alkaloid which has been extracted from corn lily (Veratrum californiucum). It has shown potential as an anti-tumor agent and is undergoing Phase 1 trials for FDA Approval.9

Summary

  • Causes birth defects, including cyclopia, in animals when the plant is ingested by pregnant female.
  • Targets HedgeHog (HH) signaling pathway. Strict control is critical for correct cell differentiation during embryo genesis. In adults, HH signaling plays role in regulation of stem-cell maintenance and proliferation.
  • Misregulation of HH signaling has been shown to cause tumors, including basel cell carcinoma, medulloblastoma, small cell lung cancer, pancreatic adenocarcinoma, and some prostrate cancers.
  • HH signaling has also been shown to be important in the maintenance of breast, brain, and clorectal cancers. Shows very selective activity against HH-dependent tumors and is well tolerated. Able to target cancer stem cells that are linked to cancer reoccurrence.

Chemical Structure of Cyclopamine
Cyclopamine

Solubility

Cyclopamine is partially soluble in, Methanol, Ethanol, DMSO and Benzene at room temperature, but will precipitate out at -20°C. Cyclopamine is freely soluble in Methylene Chloride and Chloroform.

References

1. Taipale, J. et al. Nature 406 944-945 (2000).
2. Chen, J.K. et al. Genes & Development 16: 2743-2748 (2002).
3. Incardona, J.P., et al. Development. 125: 3553-3562 (1998).
4. Qualtrough, D. et al. International Journal of Cancer. 110 831-837 (2004).
5. Tabs, S., and Avci, O. Eur J Dermatol. 14: 96-102 (2004).
6. Gary V. Borzillo et. al. Current Topics in Medical Chemistry 5: 147-157 (2005)
7. M. Harper, The curious case of the one eyed sheep, www.forbes.com/global/2005/1128/066A-print/html (2005)
8. Katano, M. et al. Cancer Letters. 227; 99-104 (2005)
9. Curis/Genetech, Skin Cream targeting basal cell melanoma